Sodium Bicarbonate → 1-(4-(5-Isopropyl-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

HRID 2386231노트

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HRID 2386231 반응식
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:7](=[O:15])[C:6]3([CH3:20])[CH2:16][O:17][CH2:18][CH2:19][N:5]3[C:4]=2[N:3]=1.[CH3:21][NH:22][C:23]([NH:25][C:26]1[CH:31]=[CH:30][C:29](B2OC(C)(C)C(C)(C)O2)=[CH:28][CH:27]=1)=[O:24].C(=O)(O)[O-].[Na+]>O1CCOCC1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[CH:12]([N:8]1[C:7](=[O:15])[C:6]2([CH3:20])[CH2:16][O:17][CH2:18][CH2:19][N:5]2[C:4]2[N:3]=[C:2]([C:29]3[CH:28]=[CH:27][C:26]([NH:25][C:23]([NH:22][CH3:21])=[O:24])=[CH:31][CH:30]=3)[N:11]=[CH:10][C:9]1=2)([CH3:14])[CH3:13]

참가 물질

6

반응물 3

HCID 516892Sodium BicarbonateHCID 177502733-Methyl-1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ureaHCID 866515712-chloro-5-isopropyl-6a-methyl-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one

생성물 1

HCID 513520731-(4-(5-Isopropyl-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea수율 22.1%

시약·촉매·용매 2

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)촉매HCID 312751,4-Dioxane용매

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온도
100 °C

실험 절차

2-Chloro-5-isopropyl-6a-methyl-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one (98 mg, 0.330 mmol) was mixed with PdCl2(dppf) (48.3 mg), 1-methyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (100 mg, 0.363 mmol) and saturated sodium bicarbonate solution (2 mL, sat.) in 1,4-dioxane (4 mL). The suspension was heated by microwave irradiation at 100° C. for 30 minutes. The suspension was filtered, the solids washed with methanol then DMSO and the filtrate evaporated in vacuo. The resulting solid was purified by mass triggered preparative HPLC eluted with 20-35% of ACN (containing 0.035% TFA) in water (containing 0.05% TFA) on a Phenomenex Gemini 5 μm C18, 75×30 mm column) to give the title compound (30 mg 22% yield) as a pale yellow solid. 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.55 (m, 6H) 1.62 (s, 3H) 2.80 (s, 3H) 3.50 (td, J=12, 4 Hz, 1H) 3.68 (td, J=12, 4 Hz, 1H) 3.79 (d, J=12 Hz, 1H) 4.14 (m, 1H) 4.62 (dd, J=12, 4 Hz, 1H) 4.66 (m, 1 H) 7.62 (d, J=8 Hz, 2H) 8.10 (d, J=8 Hz, 2H) 8.13 (s, 1H). MS [M+H] Found 411.

후처리

  1. filtrationThe suspension was filtered
  2. washthe solids washed with methanol
  3. customDMSO and the filtrate evaporated in vacuo
  4. customThe resulting solid was purified by mass
  5. washeluted with 20-35% of ACN (containing 0.035% TFA) in water (containing 0.05% TFA) on a Phenomenex Gemini 5 μm C18, 75×30 mm column)

출처 및 근거

ORD 기록
ord-d4762c80d9864a28a71040ea7cebdc1a
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268819B2

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