Fluoresone → 4-(4-Ethanesulfonyl-phenoxy)-6-fluoro-3-methyl-naphthalene-2-carbaldehyde
반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([CH:12]=[O:13])[C:6]([CH3:14])=[C:5]2[OH:15].[CH2:16]([S:18]([C:21]1[CH:26]=[CH:25][C:24](F)=[CH:23][CH:22]=1)(=[O:20])=[O:19])[CH3:17]>>[CH2:16]([S:18]([C:21]1[CH:26]=[CH:25][C:24]([O:15][C:5]2[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=3)[CH:8]=[C:7]([CH:12]=[O:13])[C:6]=2[CH3:14])=[CH:23][CH:22]=1)(=[O:19])=[O:20])[CH3:17]참가 물질
3
실험 절차
Starting with 6-fluoro-4-hydroxy-3-methyl-naphthalene-2-carbaldehyde (115 mg, 0.6 mmol) and 1-ethanesulfonyl-4-fluoro-benzene (226 mg, 1.2 mmol), using a method analogous to the one described for the methyl ester of example 1-1,4-(4-ethanesulfonyl-phenoxy)-6-fluoro-3-methyl-naphthalene-2-carbaldehyde (120 mg, 57%) was obtained as a yellow solid which was used in the next step without further purification. 1H NMR (400 MHz, CDCl3) δ ppm 10.35 (s, 1H), 8.32 (s, 1H), 8.07 (dd, J=8.97, 5.68 Hz, 1H), 7.84 (d, J=9.09 Hz, 2H), 7.33-7.45 (m, 2H), 6.94 (d, J=8.84 Hz, 2H), 3.12 (q, J=7.41 Hz, 2H), 2.59 (s, 3H), 1.31 (t, J=7.45 Hz, 3H).
후처리
- customwas obtained as a yellow solid which