Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tyramine → 4-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tyramine | HCID 5610 | — |
| 반응물 | 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine | HCID 86603261 | — |
| 생성물 | 4-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol | HCID 67045057 | 35% |
반응 단계
Intermediate 26 was coupled with tyramine following procedure F. The product was purified by flash chromatography using 99:1 CH2Cl2:MeOH as eluent. Yield: 35%. LC-MS showed the product had the expected M+H+ of 366.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08268822B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-97d76e7e6a82413193ca79b857e8ffe9 |
| 출처 메모 | uspto-grants-2012_09 |