O-Methyltyramine → 1-(3-{2-[2-(4-Methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenyl)-ethanone

HRID 2386403

반응식

HRID 2386403 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([C:14](=[O:16])[CH3:15])[CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:4][N:3]=1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][NH2:27])=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][NH:27][C:2]2[N:7]=[C:6]([C:8]3[CH:9]=[C:10]([C:14](=[O:16])[CH3:15])[CH:11]=[CH:12][CH:13]=3)[CH:5]=[CH:4][N:3]=2)=[CH:21][CH:20]=1

참가 물질

3

반응물 2

HCID 4657O-MethyltyramineHCID 249018391-[3-(2-Chloro-pyrimidin-4-yl)-phenyl]-ethanone

생성물 1

HCID 670455401-(3-{2-[2-(4-Methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenyl)-ethanone

실험 절차

Intermediate 38 was coupled with 2-(4-Methoxy-phenyl)-ethylamine following procedure F. LC-MS showed the product had the expected M+H+ of 348.

출처 및 근거

ORD 기록
ord-d5ddaf116a304e2bbf28d4dbf4b217ab
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268822B2

연결된 노트

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