2,4-Dichloropyrimidine → 4-(4-Ethoxy-phenyl)-2-chloro-pyrimidine

HRID 2386413노트

반응식

HRID 2386413 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH2:9]([O:11][C:12]1[CH:13]=[C:14](B(O)O)[CH:15]=[CH:16][CH:17]=1)[CH3:10]>>[CH2:9]([O:11][C:12]1[CH:13]=[CH:14][C:15]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=2)=[CH:16][CH:17]=1)[CH3:10]

참가 물질

3

반응물 2

HCID 775312,4-DichloropyrimidineHCID 27739203-Ethoxybenzeneboronic acid

생성물 1

HCID 249019794-(4-Ethoxy-phenyl)-2-chloro-pyrimidine

실험 절차

2,4 dichloropyrimidine was coupled with 3-ethoxyphenylboronic acid following procedure A. LC-MS showed the product had the expected M+H+ of 235.

출처 및 근거

ORD 기록
ord-3960d1832f51486db6cac761acfaf7fb
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268822B2

반응 노트

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