2,4-Dichloropyrimidine → 5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde

HRID 2386470

반응식

HRID 2386470 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[CH:15][C:16]=1[F:17])=[O:10]>>[Cl:1][C:2]1[N:7]=[C:6]([C:13]2[CH:14]=[CH:15][C:16]([F:17])=[C:11]([CH:12]=2)[CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 775312,4-DichloropyrimidineHCID 2778651(4-Fluoro-3-formylphenyl)boronic acid

생성물 1

HCID 249019815-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde

실험 절차

2,4 dichloropyrimidine and 3-formyl 4-fluorophenyl boronic acid were coupled following procedure A. LC-MS showed the product was >95% pure and had the expected M+H+ of 237.

출처 및 근거

ORD 기록
ord-5e9a4535f4724e70857854daaf2e163c
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268822B2

연결된 노트

불러오는 중…