Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tyramine → 4-[2-(4-{3-[(Azetidin-3-yl-ethyl-amino)-methyl]-phenyl}-pyrimidin-2-ylamino)-ethyl]-phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tyramine | HCID 5610 | — |
| 반응물 | 3-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-azetidine-1-carboxylic acid tert-butyl ester | HCID 86603299 | — |
| 생성물 | 4-[2-(4-{3-[(Azetidin-3-yl-ethyl-amino)-methyl]-phenyl}-pyrimidin-2-ylamino)-ethyl]-phenol | HCID 58603750 | — |
반응 단계
Intermediate 105 was coupled with tyramine following procedure F. The resulting product was deprotected following procedure G2. LC-MS showed the product had the expected M+H+ of 405. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.69 (s, 1H), 8.40 (d, 1H), 8.34 (s, 1H), 7.96 (d, 1H), 7.72 (t, 1H), 7.68 (d, 1H), 7.11 (d, 2H), 6.67 (d, 2H), 4.56 (m, 5H), 3.78 (m, 4H), 3.21 (q, 2H), 2.93 (t, 2H), 1.39 (t, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08268822B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-502b9d68993141ecac0f4d3076fab90a |
| 출처 메모 | uspto-grants-2012_09 |