3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde → HCID 86603304, 화합물

반응식

[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH:24]1[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][N:26]([CH2:11][C:10]2[CH:13]=[CH:14][CH:15]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:9]=2)[CH2:25][CH:24]1[CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)=[O:22])([CH3:19])([CH3:17])[CH3:18]

참가 물질

반응물 2

HCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

HCID 44118663tert-Butyl 2-benzylpiperazine-1-carboxylate

생성물 1

HCID 86603304HCID 86603304, 화합물

실험 절차

Intermediate 1 was coupled with 2-Benzyl-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 479.

출처 및 근거

ORD 기록: ord-8148988416a74a56a9d10df9dc1c9725
출처 데이터셋: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08268822B2

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