2,4-Dichloropyrimidine → 3-(2-Chloropyrimidin-4-yl)-4-methoxybenzaldehyde

HRID 2386562

반응식

HRID 2386562 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:12]=[CH:13][C:14]([O:20][CH3:21])=[C:15](B(O)O)[CH:16]=1)=[O:10]>>[Cl:1][C:2]1[N:7]=[C:6]([C:13]2[CH:12]=[C:11]([CH:16]=[CH:15][C:14]=2[O:20][CH3:21])[CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 775312,4-DichloropyrimidineHCID 27343675-Formyl-2-methoxyphenylboronic acid

생성물 1

HCID 249018763-(2-Chloropyrimidin-4-yl)-4-methoxybenzaldehyde수율 70%

실험 절차

2,4 dichloropyrimidine and 5-formyl-2-methoxyphenylboronic acid was coupled following procedure A. The yield was 70%. LC-MS showed the product was >95% pure and had the expected M+H+ of 249. 1H NMR (Varian 300 MHz, MeOD-d6, shifts relative to the solvent peak at 3.33 ppm) δ 9.9 (s, 1H) 8.7 (d, 1H) 8.4 (s, 1H) 8.0 (d, 2H) 7.4 (d, 1H) 3.9 (s, 3H).

출처 및 근거

ORD 기록
ord-b40de3aebce94360b7f3158ef094e7e1
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268822B2

연결된 노트

불러오는 중…