8-chloro-3-(2-cyclopropylethyl)-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione → [8-chloro-3-(2-cyclopropylethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl]acetonitrile

HRID 2386639

반응식

HRID 2386639 반응식
[Cl:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[N:7]([CH2:12][C:13]#[N:14])[C:6](=[O:15])[N:5]([CH2:16][CH2:17][CH3:18])[C:4]=2[N:3]=1.ClC1N(CC=C)[C:27]2C(=O)NC(=O)N(CCC3CC3)[C:22]=2N=1>>[Cl:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[N:7]([CH2:12][C:13]#[N:14])[C:6](=[O:15])[N:5]([CH2:16][CH2:17][CH:18]3[CH2:27][CH2:22]3)[C:4]=2[N:3]=1

참가 물질

3

반응물 2

HCID 592995418-chloro-3-(2-cyclopropylethyl)-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dioneHCID 59299547(8-chloro-2,6-dioxo-3-propyl-2,3,6,7-tetrahydro-1H-purin-1-yl)acetonitrile

생성물 1

HCID 11737943[8-chloro-3-(2-cyclopropylethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl]acetonitrile

실험 절차

Prepared as (8-chloro-2,6-dioxo-3-propyl-2,3,6,7-tetrahydro-1H-purin-1-yl)acetonitrile (example 23) using 8-chloro-3-(2-cyclopropylethyl)-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione.

출처 및 근거

ORD 기록
ord-93fe5992a45f4a2088c8a901c859cf50
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268839B2

연결된 노트

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