Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methoxycarbonylphenylboronic acid → 4-{3-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-propyl]-phenoxy}-benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methoxycarbonylphenylboronic acid | HCID 2734369 | — |
| 반응물 | 6-[(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-4-methyl-4H-benzo[1,4]oxazin-3-one | HCID 66697239 | — |
| 촉매 | Cupric acetate | HCID 8895 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 4-{3-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-propyl]-phenoxy}-benzoic acid methyl ester | HCID 66697408 | — |
반응 단계
In analogy to Example 5, 6-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-4-methyl-4H-benzo[1,4]oxazin-3-one (Example 56, step 4) was reacted with 4-methoxycarbonyl-phenylboronic acid, copper-(II)-acetate and pyridine to give the title compound as a white solid. MS (m/e, ISP neg. ion)=548.2 [M−H+]
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08268820B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-e6c28bfe737f40b58dd81d5e911668de |
| 출처 메모 | uspto-grants-2012_09 |