Methanol → Methyl 2-chloro-5-(trifluoromethyl)pyridine-4-carboxylate
반응식
[C:1](Cl)(=O)C(Cl)=O.[Cl:7][C:8]1[CH:9]=[C:10]([C:14]([C:17]([F:20])([F:19])[F:18])=[CH:15][N:16]=1)[C:11]([OH:13])=[O:12].CO>C(Cl)Cl.CN(C=O)C>[CH3:1][O:12][C:11](=[O:13])[C:10]1[C:14]([C:17]([F:20])([F:18])[F:19])=[CH:15][N:16]=[C:8]([Cl:7])[CH:9]=1참가 물질
6
실험 절차
Oxalyl chloride (0.5 ml) was added to a solution of 2-chloro-5-(trifluoromethyl)isonicotinic acid (CAS Reg. No. 505084-58-2, 68 mg) in DCM (5 ml). DMF (1 drop) was added and the resulting mixture was stirred overnight at room temperature. Methanol (5 ml) was added and the mixture was concentrated to dryness. The crude product was used in the next step without further purification.
후처리
- concentrationthe mixture was concentrated to dryness
- customThe crude product was used in the next step without further purification
출처 및 근거
- ORD 기록
- ord-392ec75cd9614ab18dd961e4217e665d
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08268820B2
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