4-Aminophenol → 2-ethyl-3-(4-hydroxyphenyl)quinazolin-4(3H)-one

HRID 2386923노트

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HRID 2386923 반응식
[CH2:1]([C:3]1O[C:7](=[O:9])[C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[N:4]=1)[CH3:2].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1>CN(C)C=O>[CH2:1]([C:3]1[N:14]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)[C:7](=[O:9])[C:6]2[C:5](=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 4034-AminophenolHCID 9285262-Ethyl-benzo[d][1,3]oxazin-4-one

생성물 1

HCID 7113732-ethyl-3-(4-hydroxyphenyl)quinazolin-4(3H)-one수율 66%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
140 °C

실험 절차

2-ethyl-4H-3,1-benzoxazin-4-one (6.5 g, 37.1 mmol) and 4-aminophenol (4.05 g, 37.1 mmol) were dissolved in dimethylformamide (18 mL) and stirred at 140° C. for 10 hours. After leaving to cool to room temperature, distilled water (94 mL) was added, and the solid precipitate was filtered off. The product was recrystallized (ethanol) and the target compound (6.52 g, 66%) was obtained as light brown crystals.

후처리

  1. customAfter leaving
  2. temperatureto cool to room temperature
  3. distillationdistilled water (94 mL)
  4. additionwas added
  5. filtrationthe solid precipitate was filtered off
  6. customThe product was recrystallized (ethanol)

출처 및 근거

ORD 기록
ord-b7d9c0b56f054245baa56458c6fd3246
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268842B2

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