N4-(2-aminoethyl)pyrimidine-2,4-diamine dihydrochloride → N4-{2-[(2-aminopyrimidin-4-yl)amino]ethyl}-8-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidine-2,4-diamine

HRID 2386998노트

반응식

HRID 2386998 반응식
CC1C=CC(S(O[C:12]2[C:13]3[CH2:23][CH2:22][CH2:21][CH:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:19][C:14]=3[N:15]=[C:16]([NH2:18])[N:17]=2)(=O)=O)=CC=1.Cl.Cl.[NH2:32][CH2:33][CH2:34][NH:35][C:36]1[CH:41]=[CH:40][N:39]=[C:38]([NH2:42])[N:37]=1>>[NH2:42][C:38]1[N:37]=[C:36]([NH:35][CH2:34][CH2:33][NH:32][C:14]2[C:13]3[CH2:23][CH2:22][CH2:21][CH:20]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:19][C:12]=3[N:17]=[C:16]([NH2:18])[N:15]=2)[CH:41]=[CH:40][N:39]=1

참가 물질

3

반응물 2

HCID 86638141N4-(2-aminoethyl)pyrimidine-2,4-diamine dihydrochlorideHCID 866381472-amino-8-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-4-yl 4-methylbenzenesulfonate

생성물 1

HCID 44609257N4-{2-[(2-aminopyrimidin-4-yl)amino]ethyl}-8-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidine-2,4-diamine

실험 절차

The product from Example 11C (102 mg, 0.248 mmol) and the product from Example 1E (73 mg, 0.323 mmol) were treated under the conditions of Example 1F to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.09-1.29 (m, 2H) 1.70-2.02 (m, 3H) 2.22-2.63 (m, 2H) 2.71 (dd, J=15.47, 5.16 Hz, 1H) 3.06-3.27 (m, 2H) 3.34-3.50 (m, 3H) 5.56-5.65 (m, 2H) 5.70-5.78 (m, 1H) 5.87 (s, 2H) 6.52 (s, 1H) 6.90 (s, 1H) 7.10-7.34 (m, 5H) 7.61 (d, J=5.55 Hz, 1H); MS (ESI+) m/z 391.1 (M+H)+.

출처 및 근거

ORD 기록
ord-b31c51eafd6c4c01a94449fe2732ed3b
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268846B2

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