Morpholine → 4-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

HRID 2387212노트

반응식

HRID 2387212 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)(=[O:10])=[O:9])[CH:7]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 866319035-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride

생성물 1

HCID 686302274-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

5-Chloro-2-trifluoromethyl-benzenesulfonyl chloride (0.17 g, 0.62 mmol) is added to a solution of morphline (0.114 ml, 1.3 mol) in DCM (5 ml) and the resulting white suspension is stirred at room temperature overnight. The reaction mixture is diluted with DCM (5 ml), and washed with 0.1M HCl, dried (MgSO4) and concentrated in vacuo to yield the title compound. [M+H]+ 330.

후처리

  1. washwashed with 0.1M HCl
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2effe0fbb10b4a01aad9934df5cfb5bf
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268834B2

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