5-(benzyloxy)-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-one → 5-hydroxy-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-one

HRID 2387750노트

반응식

HRID 2387750 반응식
C([O:8][C:9]1[C:10](=[O:20])[N:11]([CH2:17][O:18][CH3:19])[C:12]([CH3:16])=[N:13][C:14]=1[CH3:15])C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[C].[Pd]>[OH:8][C:9]1[C:10](=[O:20])[N:11]([CH2:17][O:18][CH3:19])[C:12]([CH3:16])=[N:13][C:14]=1[CH3:15]

참가 물질

5

반응물 2

HCID 672837945-(benzyloxy)-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 672821145-hydroxy-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-one수율 100.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

The compound 326-4 (1.42 g) was dissolved in ethyl acetate (30 ml). Palladium-carbon (700 mg) was added to the solution, and the obtained mixture was stirred in a hydrogen atmosphere for 1 hour. The reaction mixture was filtered with Celite, and the filtrate was concentrated under reduced pressure, so as to obtain the crude title compound (954 mg).

후처리

  1. filtrationThe reaction mixture was filtered with Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5e642718ffdb43dc91d15ba560a443c5
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268848B2

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