Trifluoroacetic acid → (S)-3-(Benzyl((S)-1-phenylethyl)amino)heptanoic acid

HRID 2387789노트

반응식

HRID 2387789 반응식
[CH2:1]([N:8]([C@H:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH3:23])[C@@H:9]([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([N:8]([C@H:22]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH3:23])[C@@H:9]([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][C:11]([OH:13])=[O:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68104424(S)-tert-Butyl 3-(benzyl((S)-1-phenylethyl)amino)heptanoate

생성물 1

HCID 68414644(S)-3-(Benzyl((S)-1-phenylethyl)amino)heptanoic acid수율 165.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The product from step (ii) (12 g) was dissolved in DCM (40 mL) and TFA (2 mL) and the reaction mixture stirred for 24 h. The solvents were evaporated to give the subtitle compound 17 g.

후처리

  1. customThe solvents were evaporated

출처 및 근거

ORD 기록
ord-fd8c30d190f34c6b9d0683c009fca8f1
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268990B2

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