Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Cyanide → 2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | 4-Chloro-5-(4-(chloromethyl)-2-fluorobenzyl)-6-methylpyrimidin-2-amine | HCID 86633404 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetonitrile | HCID 86633405 | — |
반응 단계
Potassium cyanide (0.056 g) was added to a stirred solution of the product from step (ii) (0.13 g) in DMSO (1 mL) and DMF (1 mL). The mixture was stirred at rt for 15 h and then diluted with EtOAc (10 mL). The organic phase was washed with water and brine then dried, filtered and evaporated to give the subtitle compound, 0.12 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08268990B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-8d0c87902e204e5db037e8e0f1c279e0 |
| 출처 메모 | uspto-grants-2012_09 |