Carbonic acid-guanidine (1:1) → HCID 178493423, 화합물

HRID 2387851노트

반응식

HRID 2387851 반응식
[OH:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][CH:7]([C:13](=O)[CH3:14])[C:8](OCC)=[O:9])=[C:4]([O:18][CH3:19])[CH:3]=1.C(=O)(O)O.[NH2:24][C:25]([NH2:27])=[NH:26]>CCO>[NH2:27][C:25]1[N:26]=[C:8]([OH:9])[C:7]([CH2:6][C:5]2[CH:16]=[CH:17][C:2]([OH:1])=[CH:3][C:4]=2[O:18][CH3:19])=[C:13]([CH3:14])[N:24]=1

참가 물질

4

반응물 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 68415133Ethyl 2-(4-hydroxy-2-methoxybenzyl)-3-oxobutanoate

생성물 1

HCID 178493423HCID 178493423, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of the product from step (ii) (23.35 g) and guanidine carbonate (15.9 g) in EtOH (300 ml) was heated under reflux for 24 h. The mixture was cooled and the solid filtered and washed with EtOH, water, EtOH then diethyl ether and dried to afford the subtitle compound, 11.36 g.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 24 h
  3. temperatureThe mixture was cooled
  4. filtrationthe solid filtered
  5. washwashed with EtOH, water, EtOH
  6. dry with materialdiethyl ether and dried

출처 및 근거

ORD 기록
ord-5556f0b6ab3045b69709ac0ecf8a097e
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268990B2

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