Imidazole → HCID 86633411, 화합물

HRID 2387866노트

반응식

HRID 2387866 반응식
[NH2:1][CH2:2][C@@H:3]([OH:6])[CH2:4][CH3:5].[C:7]([Si:11](Cl)([CH3:13])[CH3:12])([CH3:10])([CH3:9])[CH3:8].N1C=CN=C1>CN(C=O)C>[Si:11]([O:6][C@@H:3]([CH2:4][CH3:5])[CH2:2][NH2:1])([C:7]([CH3:10])([CH3:9])[CH3:8])([CH3:13])[CH3:12]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 6995554(2S)-1-Amino-2-butanol

생성물 1

HCID 86633411HCID 86633411, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To the product from step (ii) (310 mg) in DMF (10 mL), tert-butylchlorodimethylsilane (734 mg) was added followed by imidazole (474 mg) and stirred at rt for 24 h. The mixture was washed with water and extracted with EtOAc, dried and the solvent removed to give the subtitle compound as a yellow oil, 610 mg.

후처리

  1. washThe mixture was washed with water
  2. extractionextracted with EtOAc
  3. customdried
  4. customthe solvent removed

출처 및 근거

ORD 기록
ord-b3232efce3c34bd9b858e2e9481ecf73
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268990B2

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