Acetic Acid → HCID 178433372, 화합물

HRID 2387887노트

반응식

HRID 2387887 반응식
[C:1]([CH2:3][C:4]1[CH:18]=[CH:17][C:7]([CH2:8][CH:9]([C:14](=O)[CH3:15])[C:10](OC)=[O:11])=[CH:6][CH:5]=1)#[N:2].[NH2:19][C:20]([NH2:22])=[NH:21].C(O)(=O)C>CCO>[NH2:22][C:20]1[N:21]=[C:10]([OH:11])[C:9]([CH2:8][C:7]2[CH:17]=[CH:18][C:4]([CH2:3][C:1]#[N:2])=[CH:5][CH:6]=2)=[C:14]([CH3:15])[N:19]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 3520GuanidineHCID 59590640Methyl 2-(4-(cyanomethyl)benzyl)-3-oxobutanoate

생성물 1

HCID 178433372HCID 178433372, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of the crude product from step (i) and guanidine (16 g) in EtOH (350 ml) was heated under reflux for 5 h. The mixture was cooled, neutralised with acetic acid, and the solid filtered and dried, 22.1 g.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 5 h
  3. temperatureThe mixture was cooled
  4. filtrationthe solid filtered
  5. customdried

출처 및 근거

ORD 기록
ord-5b16fe2b445c4de69d59080041956064
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268990B2

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