1-Butanol → (S)-2-(4-((2-Amino-4-(2-hydroxybutylamino)-6-methylpyrimidin-5-yl)methyl)phenyl)acetic acid

참여 물질

역할	이름	HCID	투입량
반응물	1-Butanol	HCID 263	—
반응물	Potassium Hydroxide	HCID 14797	—
반응물	N'-[5-[[4-(cyanomethyl)phenyl]methyl]-4-[(5S)-5-ethyl-2-oxo-1,3-oxazolidin-3-yl]-6-methylpyrimidin-2-yl]-N,N-dimethylmethanimidamide	HCID 87445299	—
생성물	(S)-2-(4-((2-Amino-4-(2-hydroxybutylamino)-6-methylpyrimidin-5-yl)methyl)phenyl)acetic acid	HCID 68414496	—

반응 조건

온도	100 °C

반응 단계

Aq. 5M KOH (1 ml) was added to a stirred solution of the product from step (vi) (136 mg) in butan-1-ol (2 mL). The solution was heated at 100° C. for 15 h and the solvent evaporated under reduced pressure. The residue was diluted with MeOH (2 mL) and the pH adjusted to ˜7 using acetic acid. The solution was purified by RPHPLC to give the subtitle compound as a white solid, 55 mg.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08268990B2
출처 데이터셋	uspto-grants-2012_09
ORD ID	ord-83c5fbf70268443dbfb08f83aa949616
출처 메모	uspto-grants-2012_09