Ethanol → 2-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetic acid

HRID 2387910노트

반응식

HRID 2387910 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([S:13][C:14]2[CH:19]=[CH:18][C:17](CC#N)=[CH:16][CH:15]=2)=[C:4]([CH3:23])[N:3]=1.[OH-:24].[K+].[CH3:26][CH2:27][OH:28]>>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:26][C:27]([OH:24])=[O:28])=[CH:16][CH:15]=2)=[C:4]([CH3:23])[N:3]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 684153862-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetonitrile

생성물 1

HCID 684157402-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetic acid

실험 절차

A mixture of the product from step (v) (610 mg) and aq. SM KOH (2 ml) in EtOH (8 ml) was heated under reflux for 18 h. The mixture was purified by RPHPLC to give the subtitle compound as a solid, 392 mg.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 18 h
  3. customThe mixture was purified by RPHPLC

출처 및 근거

ORD 기록
ord-b350b676971f41718a70ebfa290db11a
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268990B2

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