Potassium Hydroxide → 3543-21-3

HRID 2387952노트

반응식

HRID 2387952 반응식
[OH-].[K+].C(OC([N:13]1[CH2:18][CH2:17][C:16]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:15][CH2:14]1)=O)C1C=CC=CC=1.CO.C(Cl)(Cl)Cl>C(O)C>[C:24]1([C:16]2([N:19]3[CH2:20][CH2:21][CH2:22][CH2:23]3)[CH2:15][CH2:14][NH:13][CH2:18][CH2:17]2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 21584188Chloroform methanolHCID 67366133HCID 67366133, 화합물

생성물 1

HCID 594016893543-21-3수율 151.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

11 g of KOH were added to a solution of 7.3 g (1 equiv.) of benzyloxycarbonyl-4-phenyl-4-(pyrrolidin-1-yl)piperidine in 100 ml of ethanol, and the reaction mixture was heated for 24 hours at reflux. The progress of the reaction was monitored by thin-layer chromatography (20% MeOH/CHCl3). When the reaction was complete, the solvent was distilled off completely, 100 ml of water were added to the residue, and extraction was carried out 3× with 100 ml of CHCl3. The combined organic phases were dried with Na2SO4. After removal of the solvent under reduced pressure, 7 g of crude product were obtained in the form of an oil.

후처리

  1. temperaturethe reaction mixture was heated for 24 hours
  2. temperatureat reflux
  3. distillationthe solvent was distilled off completely
  4. addition100 ml of water were added to the residue, and extraction
  5. dry with materialThe combined organic phases were dried with Na2SO4
  6. customAfter removal of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-baa4d7cc115d45bdbacd158e022d9ddf
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08269000B2

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