Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → HCID 178445738, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | N-Iodosuccinimide | HCID 120273 | — |
| 반응물 | HCID 178445732 | HCID 178445732 | — |
| 촉매 | Zirconium chloride (ZrCl4), (T-4)- | HCID 9856075 | — |
| 생성물 | HCID 178445738 | HCID 178445738 | 86% |
반응 단계
A mixture of (R)-4-(6-(cis-4-butylcyclohexyloxy)naphthalen-2-yl)-4-methyloxazolidin-2-one (Example 5, 113.2 mg, 0.0002967 mol), N-iodosuccinimide (74.8 mg, 0.000332 mol) and zirconium tetrachloride (10 mg, 0.000044 mol) in methylene chloride (2.43 mL, 0.0380 mol) was heated to reflux under argon in a vial overnight. The precipitate was filtered off and the residue was purified with Isco column eluted with EtOAc in hexane from 0 to 40% to give the product as a solid (128.9 mg, 86% yield). NMR showed identity.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08269043B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-76c25ea5a84f4e288d832627930b8d96 |
| 출처 메모 | uspto-grants-2012_09 |