Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
phenylalaninol, (S)- → N-[(1S)-1-Benzyl-2-hydroxyethyl]-(2S)-2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | phenylalaninol, (S)- | HCID 447213 | — |
| 반응물 | 2-[3-Fluoro-4-(metylsulfonylamino)phenyl]propion | HCID 131731183 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-[(1S)-1-Benzyl-2-hydroxyethyl]-(2S)-2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionamide | HCID 24754390 | — |
반응 단계
A mixture of 2-[3-fluoro-4-(methylsulfonylamino)phenyl]propion acid (100 mg, 0.234 mmol) and L-phenyl alaninol (71 mg, 0.468 mmol) in CH2Cl2 (3 mL) was refluxed for 3 h and concentrated in vacuo. The residue was dissolved in MeOH (2 mL) and purified by flash column chromatography on silica gel using EtOAc:hexanes (2:1) to EtOAc:MeOH (20:1) as eluant to afford N-[(1S)-1-Benzyl-2-hydroxyethyl]-(2S)-2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642657B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-09c0895840e8457380f08d0de98eabe0 |
| 출처 메모 | uspto-grants-2014_02 |