Sodium Iodide → HCID 68538779, 화합물

HRID 2389318노트

반응식

HRID 2389318 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:3]=1[NH:16][C:17](=[O:19])[CH3:18].Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23].[I-].[Na+].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[C:17]([NH:16][C:3]1[C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])(=[O:19])[CH3:18]

참가 물질

7

반응물 4

HCID 5238Sodium IodideHCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 68538324HCID 68538324, 화합물

생성물 1

HCID 68538779HCID 68538779, 화합물수율 72.6%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

To a mixture of N-[2-amino-6-(benzyloxy)phenyl]acetamide (2.95 g) and ethyl bromoacetate (2.11 g) in DMF (29.5 mL) were added sodium iodide (1.73 g) and K2CO3 (1.91 g) at ambient temperature. The mixture was stirred at 80° C. for 6 hours. After cooling, the reaction mixture was added water (50 mL). The formed precipitate was collected by filteration and washed with water and recrystallized from solvent (EtOAc and n-hexane) to give ethyl N-[2-acetamido-3-(benzyloxy)phenyl]glycinate (2.86 g) as a white solid.

후처리

  1. temperatureAfter cooling
  2. customThe formed precipitate was collected by filteration
  3. washwashed with water
  4. customrecrystallized from solvent (EtOAc and n-hexane)

출처 및 근거

ORD 기록
ord-f2ea4840a7ff4ef4966d51d9f4f7d93d
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273745B2

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