Sodium Iodide → Ethyl [3-(3-iodopropyl)phenoxy]acetate

HRID 2389354노트

반응식

HRID 2389354 반응식
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][CH:21]=1)[O:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])(=O)=O.[I-:22].[Na+].CCOC(C)=O>CC(C)=O>[I:22][CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][CH:21]=1)[O:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

참가 물질

5

반응물 3

HCID 5238Sodium IodideHCID 8857Ethyl AcetateHCID 86637907Ethyl (3-{3-[(methylsulfonyl)oxy]propyl}phenoxy)acetate

생성물 1

HCID 86637892Ethyl [3-(3-iodopropyl)phenoxy]acetate수율 83.2%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of ethyl (3-{3-[(methylsulfonyl)oxy]propyl}phenoxy)acetate (155 g) in acetone (1.55 L) was added sodium iodide (293.7 g) at ambient temperature and the mixture was stirred at the same temperature for 18 hours. EtOAc (1 L) was added to the mixture at ambient temperature and the resulting mixture was washed successively with water and brine. The organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo to afford ethyl [3-(3-iodopropyl)phenoxy]acetate (142 g) as a red oil.

후처리

  1. washthe resulting mixture was washed successively with water and brine
  2. dry with materialThe organic layer was dried over anhydrous MgSO4
  3. filtrationfiltered
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-b3e8e004cf4e4ddf9e6d9b2e2cf54fda
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273745B2

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