tert-Butyl {4-[(3-Chloro-benzo[b]thiophene-2-carbonyl)-(2-methoxy-5-pyridin-4-yl-benzyl)-amino]-cyclohexyl}-methyl-carbamate → 3-Chloro-benzo[b]thiophene-2-carboxylic acid (2-methoxy-5-pyridin-4-yl-benzyl)-(4-methylamino-cyclohexyl)-amide dihydrochloride

HRID 2389626노트

반응식

HRID 2389626 반응식
[Cl:1][C:2]1[C:3]2[CH:43]=[CH:42][CH:41]=[CH:40][C:4]=2[S:5][C:6]=1[C:7]([N:9]([CH2:25][C:26]1[CH:31]=[C:30]([C:32]2[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=2)[CH:29]=[CH:28][C:27]=1[O:38][CH3:39])[CH:10]1[CH2:15][CH2:14][CH:13]([N:16](C)[C:17](=O)OC(C)(C)C)[CH2:12][CH2:11]1)=[O:8]>O>[ClH:1].[ClH:1].[CH3:39][O:38][C:27]1[CH:28]=[CH:29][C:30]([C:32]2[CH:33]=[CH:34][N:35]=[CH:36][CH:37]=2)=[CH:31][C:26]=1[CH2:25][N:9]([CH:10]1[CH2:15][CH2:14][CH:13]([NH:16][CH3:17])[CH2:12][CH2:11]1)[C:7]([C:6]1[S:5][C:4]2[CH:40]=[CH:41][CH:42]=[CH:43][C:3]=2[C:2]=1[Cl:1])=[O:8]

참가 물질

3

반응물 1

HCID 59683559tert-Butyl {4-[(3-Chloro-benzo[b]thiophene-2-carbonyl)-(2-methoxy-5-pyridin-4-yl-benzyl)-amino]-cyclohexyl}-methyl-carbamate

생성물 1

HCID 866189723-Chloro-benzo[b]thiophene-2-carboxylic acid (2-methoxy-5-pyridin-4-yl-benzyl)-(4-methylamino-cyclohexyl)-amide dihydrochloride

시약·촉매·용매 1

HCID 962Water용매

실험 절차

tert-Butyl carbamate 116 (75 mg, 0.12 mmol) is deprotected using Method E. On removal of the solvent in vacuo, the residue obtained is dissolved in water (5 mL) and washed with TBME (3×5 mL). Reduction of the aqueous phase in vacuo affords the title product.

후처리

  1. customOn removal of the solvent in vacuo
  2. customthe residue obtained
  3. washwashed with TBME (3×5 mL)

출처 및 근거

ORD 기록
ord-83aca881af074234bb88c8fe91b335c4
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273747B2

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