4-Bromobenzyl bromide → 1-Bromo-4-((methylsulfonyl)methyl)benzene

HRID 2389662노트

반응식

HRID 2389662 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH3:10][S:11]([O-:13])=[O:12].[Na+]>CN(C=O)C.O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:11]([CH3:10])(=[O:13])=[O:12])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 685274-Bromobenzyl bromideHCID 2733271Sodium methanesulfinate

생성물 1

HCID 27614151-Bromo-4-((methylsulfonyl)methyl)benzene

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

A stirred suspension of 4-bromobenzyl bromide (1.0 g, 4.0 mmol) and sodium methanesulfinate (2.04 g, 20 mmol) in DMF (10 mL) is heated 1 h at 60° C. The reaction mixture is then cooled to RT, diluted with water (200 mL) and extracted into EtOAc (3×25 mL). The combined EtOAc phases are washed with water (2×50 mL) and brine (25 mL) then dried (MgSO4) and reduced in vacuo to afford the title compound.

후처리

  1. temperatureThe reaction mixture is then cooled to RT
  2. extractionextracted into EtOAc (3×25 mL)
  3. washThe combined EtOAc phases are washed with water (2×50 mL) and brine (25 mL)
  4. dry with materialthen dried (MgSO4)

출처 및 근거

ORD 기록
ord-8a5caa5386e04d3da1fb8d05878f75f4
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273747B2

반응 노트

불러오는 중…