rac-tert-butyl N-methyl-N-[(1s,4s)-4-aminocyclohexyl]carbamate → HCID 59683592, 화합물

HRID 2389674노트

반응식

HRID 2389674 반응식
[F:1][C:2]1[C:7]([C:8]2[CH:9]=[CH:10][C:11]([O:16][CH3:17])=[C:12]([CH:15]=2)[CH:13]=O)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:18]([O:22][C:23](=[O:33])[N:24]([CH:26]1[CH2:31][CH2:30][CH:29]([NH2:32])[CH2:28][CH2:27]1)[CH3:25])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23](=[O:33])[N:24]([CH:26]1[CH2:27][CH2:28][CH:29]([NH:32][CH2:13][C:12]2[CH:15]=[C:8]([C:7]3[C:2]([F:1])=[N:3][CH:4]=[CH:5][CH:6]=3)[CH:9]=[CH:10][C:11]=2[O:16][CH3:17])[CH2:30][CH2:31]1)[CH3:25])([CH3:21])([CH3:19])[CH3:20]

참가 물질

3

반응물 2

HCID 21938422rac-tert-butyl N-methyl-N-[(1s,4s)-4-aminocyclohexyl]carbamateHCID 59683526HCID 59683526, 화합물

생성물 1

HCID 59683592HCID 59683592, 화합물

실험 절차

Following the synthetic protocol described in Method C′; {4-[5-(2-Fluoro-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamic acid tert-butyl ester is prepared starting from 5-(2-Fluoro-pyridin-3-yl)-2-methoxy-benzaldehyde and (4-Amino-cyclohexyl)-methyl-carbamic acid tert-butyl ester. The desired product is isolated in 70%.

후처리

  1. custom{4-[5-(2-Fluoro-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamic acid tert-butyl ester is prepared

출처 및 근거

ORD 기록
ord-fb66972624b848cbad06f9373310dee9
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273747B2

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