N-(4-Bromophenyl)-N-methyl-formamide → (4-{[4-Fluoro-4'-(formyl-methyl-amino)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester

HRID 2389721노트

반응식

HRID 2389721 반응식
[C:1]([N:8]([CH3:27])[CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][CH2:16][C:17]2[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][C:22]=2[F:23])[CH2:11][CH2:10]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Br[C:29]1[CH:34]=[CH:33][C:32]([N:35]([CH3:38])[CH:36]=[O:37])=[CH:31][CH:30]=1>>[C:4]([O:3][C:1](=[O:2])[N:8]([CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][CH2:16][C:17]2[CH:18]=[C:19]([C:29]3[CH:34]=[CH:33][C:32]([N:35]([CH:36]=[O:37])[CH3:38])=[CH:31][CH:30]=3)[CH:20]=[CH:21][C:22]=2[F:23])[CH2:11][CH2:10]1)[CH3:27])([CH3:7])([CH3:6])[CH3:5]

참가 물질

3

반응물 2

HCID 15004464N-(4-Bromophenyl)-N-methyl-formamideHCID 597669043-{[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-fluoro-benzene boronic acid

생성물 1

HCID 59766952(4-{[4-Fluoro-4'-(formyl-methyl-amino)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester

실험 절차

The title compound was prepared from boronic acid (247) (300 mg, 0.79 mmol) and aryl bromide (51) (200 mg, 0.95 mmol) in accordance with Method B.

출처 및 근거

ORD 기록
ord-ec7d72cd24764cf09ddbba8bb9ded881
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273747B2

반응 노트

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