Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Erlotinib Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| 반응물 | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | HCID 11289942 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Erlotinib Hydrochloride | HCID 176871 | 84.4% |
반응 단계
5.0 g of 4-chloro-6,7-bis(2-methoxyethoxy) quinazoline was suspended in 75 ml of water and 2.55 g of 3-aminophenyl acetylene was added at 25-30° C. followed by 1.0 ml of 50% hydrochloric acid. The reaction mass was heated at 35- 40° C. for 1 hour. The solid obtained was filtered and washed with water. The product was dried at 40-45° C. to obtain 5.8 g of erlotinib hydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642758B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-822db084f00c47e49c48714e4525ecda |
| 출처 메모 | uspto-grants-2014_02 |