Methylamine → 6-Bromo-8-isopropyl-4-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

HRID 2389967노트

반응식

HRID 2389967 반응식
[Br:1][C:2]1[C:15](=[O:16])[N:14]([CH:17]([CH3:19])[CH3:18])[C:5]2[N:6]=[C:7](S(C)=O)[N:8]=[C:9]([CH3:10])[C:4]=2[CH:3]=1.[CH3:20][NH2:21]>O1CCOCC1>[Br:1][C:2]1[C:15](=[O:16])[N:14]([CH:17]([CH3:19])[CH3:18])[C:5]2[N:6]=[C:7]([NH:21][CH3:20])[N:8]=[C:9]([CH3:10])[C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 592589926-bromo-8-isopropyl-4-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

생성물 1

HCID 592589706-Bromo-8-isopropyl-4-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
110 °C

실험 절차

To a stirred solution of 6-bromo-8-isopropyl-4-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one (175 mg, 0.508 mmol) in 1,4-dioxane (2.5 mL) was added methyl amine (0.80 mL, 2.0 M in THF, 1.6 mmol). The mixture was sealed and heated at 110° C. microwave for 15 min. The solvent was evaporated and the crude product was washed with EtOAc/Hexane to give the title compound (158 mg, 76%).

후처리

  1. customThe mixture was sealed
  2. customThe solvent was evaporated
  3. washthe crude product was washed with EtOAc/Hexane

출처 및 근거

ORD 기록
ord-ee43ed971747449299e48dbf58db3332
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273755B2

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