HCID 20566241, 화합물 → HCID 25158199, 화합물
반응식
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][CH:7]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([F:17])[CH:14]=3)[CH2:9][NH:8]2)=[CH:4][CH:3]=1.C([CH:27]1[CH2:36][C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][NH:28]1)C1C=CC=CC=1>>[C:5]([C:33]1[CH:32]=[CH:31][C:30]([CH2:29][NH:28][CH2:27][CH2:36][N:8]2[CH:7]([CH2:6][C:5]3[CH:18]=[CH:19][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([F:17])[CH:14]=3)[CH2:9]2)=[CH:35][CH:34]=1)([CH3:18])([CH3:6])[CH3:4]참가 물질
3
실험 절차
The reaction and treatment were carried out in the same manner as in Example 78 using 3-(4-chlorobenzyl)-6-fluoro-1,2,3,4-tetrahydroisoquinoline obtained in Example 55-a) instead of 3-benzyl-1,2,3,4-tetrahydroisoquinoline to obtain a title compound as a light yellow oily substance.
후처리
- customThe reaction and treatment
출처 및 근거
- ORD 기록
- ord-82a111182c234025bf74ce2042b5db95
- 출처 데이터셋
- uspto-grants-2012_09