Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromo-4-fluorobenzyl Alcohol → Tert-butyl(4-chloro-2-{[2-fluoro-5-(hydroxymethyl)phenyl]ethynyl}phenoxy)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromo-4-fluorobenzyl Alcohol | HCID 2773351 | — |
| 반응물 | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| 생성물 | Tert-butyl(4-chloro-2-{[2-fluoro-5-(hydroxymethyl)phenyl]ethynyl}phenoxy)acetate | HCID 58521982 | — |
반응 단계
Following the general method as outlined in Intermediate 19, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 3-bromo-4-fluorobenzyl alcohol (Oakwood), the title compound was obtained as a dark brown sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08273769B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-e04f653e86004338931c35289c9c0a8f |
| 출처 메모 | uspto-grants-2012_09 |