(4-Bromo-3-fluorophenyl)methanol → Tert-butyl(4-chloro-2-{[2-fluoro-4-(hydroxymethyl)phenyl]ethynyl}phenoxy)acetate

HRID 2390126

반응식

HRID 2390126 반응식
[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])([CH3:4])([CH3:3])[CH3:2].Br[C:20]1[CH:25]=[CH:24][C:23]([CH2:26][OH:27])=[CH:22][C:21]=1[F:28]>>[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[C:17][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][OH:27])=[CH:22][C:21]=1[F:28])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 20682297(4-Bromo-3-fluorophenyl)methanol2회HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2회

생성물 1

HCID 58522087Tert-butyl(4-chloro-2-{[2-fluoro-4-(hydroxymethyl)phenyl]ethynyl}phenoxy)acetate

실험 절차

Following the general method as outlined in Intermediate 19, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and (4-bromo-3-fluorophenyl)methanol (Intermediate 9), the title compound was obtained as a dark brown sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

출처 및 근거

ORD 기록
ord-2ef183e80dc648fd8586ef81daf539ab
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273769B2

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