Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → HCID 58521987, 화합물

HRID 2390130노트

반응식

HRID 2390130 반응식
[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])([CH3:4])([CH3:3])[CH3:2].I[C:20]1[CH:25]=[C:24]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:23]=[CH:22][C:21]=1[CH3:30]>>[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[C:17][C:22]1[CH:23]=[C:24]([S:26]([CH3:29])(=[O:27])=[O:28])[CH:25]=[CH:20][C:21]=1[CH3:30])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2회HCID 585220622-Iodo-1-methyl-4-(methylsulfonyl)benzene2회

생성물 1

HCID 58521987HCID 58521987, 화합물

실험 절차

Following the general method as outlined in Intermediate 20, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 2-iodo-1-methyl-4-(methylsulfonyl)benzene (Intermediate 17), the title compound was obtained as a colorless oil after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

출처 및 근거

ORD 기록
ord-7bb1ff5df47143d6a5d008086d3e9c4e
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273769B2

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