1-(2-Trimethylsilyl-1-ethynyl)-3-(propylsulfonyl)benzene → 1-Ethynyl-3-(propylsulfonyl)benzene

반응식

C(OC(=O)COC1C=CC(Cl)=CC=1C#C)(C)(C)C.C[Si](C)(C)[C:21]#[C:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([S:29]([CH2:32][CH2:33][CH3:34])(=[O:31])=[O:30])[CH:24]=1>>[C:22]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([S:29]([CH2:32][CH2:33][CH3:34])(=[O:30])=[O:31])[CH:24]=1)#[CH:21]

참가 물질

반응물 2

HCID 565942661-(2-Trimethylsilyl-1-ethynyl)-3-(propylsulfonyl)benzene2회

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate

생성물 1

HCID 565942671-Ethynyl-3-(propylsulfonyl)benzene수율 70%

실험 절차

Following the general method as outlined in Intermediate 3, starting from 1-(2-trimethylsilyl-1-ethynyl)-3-(propylsulfonyl)benzene (Intermediate 41), the title compound was obtained as a brown liquid in 70% yield after purification by column chromatography (silica) eluting with petroleum ether and ethyl acetate.

출처 및 근거

ORD 기록: ord-380274e14d2f4bf48e1829b06270b25c
출처 데이터셋: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08273769B2

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