Tetrahydrofuran → 2-Bromo-4-(isopropylsulfonyl)-1-methylbenzene

HRID 2390161노트

반응식

HRID 2390161 반응식
[Br:1][C:2]1[CH:7]=[C:6](SC(C)C)[CH:5]=[CH:4][C:3]=1[CH3:12].O[O:14][S:15]([O-:17])=O.[K+].[CH2:19]1[CH2:23]OC[CH2:20]1>O.C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[C:6]([S:15]([CH:19]([CH3:23])[CH3:20])(=[O:17])=[O:14])[CH:5]=[CH:4][C:3]=1[CH3:12]

참가 물질

6

반응물 3

HCID 8028TetrahydrofuranHCID 23707502Potassium hydroxy sulfiteHCID 585218832-Bromo-4-(isopropylthio)-1-methylbenzene

생성물 1

HCID 585220592-Bromo-4-(isopropylsulfonyl)-1-methylbenzene수율 92%

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

A cooled (0° C.) solution of 2-bromo-4-(isopropylthio)-1-methylbenzene (123 mg) in THF (10 ml) was treated with a solution of oxone (580 mg) in water (6 ml). The reaction mixture was stirred at RT for 16 hours. The reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over sodium sulfate and concentrated to give the title compound (120 mg, 92%).

후처리

  1. washwashed with water
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2cddf8cfcee24c709daf6588306fcb07
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273769B2

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