Tert-butyl{4-chloro-2-[(trimethylsilyl)ethynyl]phenoxy}acetate → {[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane

반응식

C(OC(=O)COC1C=CC(Cl)=CC=1[C:16]#[C:17][Si:18]([CH3:21])([CH3:20])[CH3:19])(C)(C)C.Br[C:24]1[CH:29]=[C:28]([S:30]([CH2:33][CH2:34][CH3:35])(=[O:32])=[O:31])[CH:27]=[CH:26][C:25]=1[F:36]>>[F:36][C:25]1[CH:26]=[CH:27][C:28]([S:30]([CH2:33][CH2:34][CH3:35])(=[O:32])=[O:31])=[CH:29][C:24]=1[C:16]#[C:17][Si:18]([CH3:21])([CH3:20])[CH3:19]

참가 물질

반응물 2

HCID 56594380Tert-butyl{4-chloro-2-[(trimethylsilyl)ethynyl]phenoxy}acetate

HCID 585220712-Bromo-1-fluoro-4-(propylsulfonyl)benzene2회

생성물 1

HCID 58521874{[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane수율 97%

실험 절차

Following the general method as outlined in Intermediate 2, starting from 2-bromo-1-fluoro-4-(propylsulfonyl)benzene (Intermediate 106) and trimethylsilylacetilene, the title compound was obtained as a brown liquid in 97% yield.

출처 및 근거

ORD 기록: ord-6c218338e49341afb37240d8cb66ae74
출처 데이터셋: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08273769B2

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