Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → 2-Ethynyl-1-fluoro-4-(propylsulfonyl)benzene

반응식

C(OC(=O)COC1C=CC(Cl)=CC=1C#C)(C)(C)C.[F:19][C:20]1[CH:25]=[CH:24][C:23]([S:26]([CH2:29][CH2:30][CH3:31])(=[O:28])=[O:27])=[CH:22][C:21]=1[C:32]#[C:33][Si](C)(C)C>>[C:32]([C:21]1[CH:22]=[C:23]([S:26]([CH2:29][CH2:30][CH3:31])(=[O:28])=[O:27])[CH:24]=[CH:25][C:20]=1[F:19])#[CH:33]

참가 물질

반응물 2

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate

HCID 58521874{[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane2회

생성물 1

HCID 585219352-Ethynyl-1-fluoro-4-(propylsulfonyl)benzene

실험 절차

Following the general method as outlined in Intermediate 3, starting from {[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane (Intermediate 107), the title compound was obtained as a brown liquid after purification by column chromatography (silica) eluting with petroleum ether and ethyl acetate.

출처 및 근거

ORD 기록: ord-7f6eecfe3e084793923a6d5c2fa75df2
출처 데이터셋: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08273769B2

반응 노트

불러오는 중…