Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → HCID 131729963, 화합물

HRID 2390222노트

반응식

HRID 2390222 반응식
[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])([CH3:4])([CH3:3])[CH3:2].Br[C:20]1[CH:21]=[C:22]([S:27]([NH:30][CH2:31][C:32]([CH3:35])([CH3:34])[CH3:33])(=[O:29])=[O:28])[CH:23]=[CH:24][C:25]=1[CH3:26]>>[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[C:17][C:20]1[CH:21]=[C:22]([S:27]([NH:30][CH2:31][C:32]([CH3:34])([CH3:33])[CH3:35])(=[O:28])=[O:29])[CH:23]=[CH:24][C:25]=1[CH3:26])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2회HCID 670080023-Bromo-N-(2,2-dimethylpropyl)-4-methylbenzenesulfonamide2회

생성물 1

HCID 131729963HCID 131729963, 화합물

실험 절차

Following the general method as outlined in Intermediate 20, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 3-bromo-N-(2,2-dimethyl-propyl)-4-methyl-benzenesulfonamide (Intermediate 145), the title compound was obtained after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

출처 및 근거

ORD 기록
ord-23229a57b3744693a6c354a12eff3153
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273769B2

반응 노트

불러오는 중…