Morpholine → 4-(3-Bromobenzoyl)morpholine

반응식

Br[C:2]1[CH:15]=[CH:14][C:5]([C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[Br:16]C1C=C(C=CC=1)C(Cl)=O.N1CCOCC1>>[Br:16][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:2]=1)[C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)=[O:7]

참가 물질

반응물 3

HCID 8083Morpholine

HCID 74377Benzoyl chloride, 3-bromo-

HCID 5321484-(4-Bromobenzoyl)morpholine

생성물 1

HCID 5319934-(3-Bromobenzoyl)morpholine수율 71%

실험 절차

Following the general method as outlined in Intermediate 174, starting from 3-bromobenzoyl chloride and morpholine, the title compound was obtained as a colorless sticky solid in 71% yield.

출처 및 근거

ORD 기록: ord-95f8b6a8aa1c4556a2d4b9781ed8041d
출처 데이터셋: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08273769B2

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