Tert-butyl{4-chloro-2-[(1,1-dioxido-2,3-dihydro-1-benzothien-6-yl)ethynyl]phenoxy}acetate → {4-Chloro-2-[(1,1-dioxido-2,3-dihydro-1-benzothien-6-yl)ethynyl]phenoxy}acetic acid

HRID 2390372노트

반응식

HRID 2390372 반응식
C([O:5][C:6](=[O:29])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[C:17][C:18]1[CH:28]=[CH:27][C:21]2[CH2:22][CH2:23][S:24](=[O:26])(=[O:25])[C:20]=2[CH:19]=1)(C)(C)C>C(Cl)Cl.CCCCC>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:29])=[O:5])=[C:10]([C:16]#[C:17][C:18]2[CH:28]=[CH:27][C:21]3[CH2:22][CH2:23][S:24](=[O:26])(=[O:25])[C:20]=3[CH:19]=2)[CH:11]=1

참가 물질

3

반응물 1

HCID 58522066Tert-butyl{4-chloro-2-[(1,1-dioxido-2,3-dihydro-1-benzothien-6-yl)ethynyl]phenoxy}acetate2회

생성물 1

HCID 46865312{4-Chloro-2-[(1,1-dioxido-2,3-dihydro-1-benzothien-6-yl)ethynyl]phenoxy}acetic acid수율 93%

시약·촉매·용매 1

HCID 21877063Dichloromethane pentane용매

실험 절차

Following the general method as outlined in Example 15, starting from tert-butyl{4-chloro-2-[(1,1-dioxido-2,3-dihydro-1-benzothien-6-yl)ethynyl]phenoxy}acetate (Intermediate 235), the title compound was obtained as a beige solid in 93% yield after trituration in DCM/pentane.

출처 및 근거

ORD 기록
ord-a54aa3c725a44c5bb3132a55a0afa9d3
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273769B2

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