Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → Ethyl 2-(4-methylphenyl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Ethyl p-tolylacetate | HCID 84175 | — |
| 반응물 | Benzeneacetic acid, alpha-methyl-, ethyl ester | HCID 99643 | — |
| 반응물 | Lithium diisopropylamide | HCID 2724682 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| 생성물 | Ethyl 2-(4-methylphenyl)propanoate | HCID 11070524 | 86% |
반응 단계
According to the procedure given for the synthesis of 202, ethyl p-tolylacetate (2.72 g, 15.2 mmol) was reacted with LDA (7.6 mL, 15.25 mmol) and methyl iodide (3.03 g, 21.30 mmol) in anhydrous THF (70 mL) and DMPU (1 mL). After aqueous workup and extraction, the residue was distilled in high vacuo to give 203 (2.5 g, 86.0%) as an oil. Bp 59-63° C./0.2 mmHg. 1H NMR (CDCl3): δ (ppm) 7.18 (d, 2 H, J=8.1), 7.10 (d, 2 H, J=8.1), 4.09 (m, 2 H), 3.67 (q, 1 H, J=7.2), 2.29 (s, 3 H), 1.47 (d, J=7.2 Hz, 3 H), 1.20 (t, J=5.7 Hz, 3 H). 13C NMR (75 MHz, CDCl3/TMS): δ (ppm) 174.71, 137.80, 136.63, 129.33, 129.14, 127.36, 60.66, 45.18, 21.05, 18.70, 14.15.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642653B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-af776805c1c24e9e8a397dbeb88e47ea |
| 출처 메모 | uspto-grants-2014_02 |