Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 5-Bromo-2-methyl-2-phenylpentan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Lithium borohydride | HCID 4148881 | — |
| 반응물 | 6-Bromo-2-methyl-2-p-tolylhexan-1-ol | HCID 11196892 | — |
| 반응물 | Ethyl 5-bromo-2-methyl-2-phenyl-pentanoate | HCID 23431358 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-Bromo-2-methyl-2-phenylpentan-1-ol | HCID 11345892 | 98.2% |
반응 단계
According to the procedure given for the synthesis of 206e, 205b (23.70 g, 79.21 mmol) was reduced with LiBH4 (3.45 g, 158.4 mmol) and methanol (5.24 g, 163.5 mmol) in anhydrous CH2Cl2 (150 mL) to give 206b (20.0 g, 98%) as an oil. 1H NMR (CDCl3): δ 7.34-7.14 (m, 5 H), 3.60 (m, 1 H), 3.48 (m, 1 H), 3.29 (t, 2 H, J=6.0), 1.96-1.44 (m, 5 H), 1.32 (s, 3 H). 13C NMR (CDCl3): δ 144.25, 128.59, 126.71, 126.41, 72.44, 43.15, 37.06, 34.64, 27.58, 21.61. HRMS (LSIMS, nba): Calcd for C12H16Br (MH+-H2O): 239.0435, found: 239.0444.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642653B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-4d171bc6f05a44ee8f0e1bd9010e9b23 |
| 출처 메모 | uspto-grants-2014_02 |