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Ammonium Chloride → N-(1-Benzyl-4-methyl-piperidin-4-yl)-benzene-1,2-diamine

HRID 239117
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인쇄 미리보기

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HRID 239117 반응식
[Cl-].[NH4+].[CH2:3]([N:10]1[CH2:15][CH2:14][C:13]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N+:24]([O-])=O)([CH3:16])[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O.CO.O1CCCC1>[CH2:3]([N:10]1[CH2:11][CH2:12][C:13]([NH:17][C:18]2[C:19]([NH2:24])=[CH:20][CH:21]=[CH:22][CH:23]=2)([CH3:16])[CH2:14][CH2:15]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 86686491(1-Benzyl-4-methyl-piperidin-4-yl)-(2-nitro-phenyl)-amine

생성물 1

HCID 86686490N-(1-Benzyl-4-methyl-piperidin-4-yl)-benzene-1,2-diamine수율 54.6%

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 8028
Tetrahydrofuran
용매

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온도
70 °C

실험 절차

168 mg ferrum was added to 160 mL ammonium chloride in 5 mL water. A solution of 244 mg (1-benzyl-4-methyl-piperidin-4-yl)-(2-nitro-phenyl)-amine in 5 mL methanol and 5 mL tetrahydrofuran were added and the mixture was stirred at 70° C. under nitrogen. The mixture was filtered over Celite and water was added to the filtrate. The solution was extracted with ethylacetate. The organic layer was evaporated to yield 121 mg of the desired product.

후처리

  1. filtrationThe mixture was filtered over Celite and water
  2. additionwas added to the filtrate
  3. extractionThe solution was extracted with ethylacetate
  4. customThe organic layer was evaporated

출처 및 근거

ORD 기록
ord-c67fc25010d84f66a439423a2d8db466
출처 데이터셋
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08642774B2

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