1-(1-Benzyl-4-methyl-piperidin-4-yl)-3-methyl-1,3-dihydro-benzoimidazol-2-one → 1-Methyl-3-(4-methyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one

HRID 239120노트

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HRID 239120 반응식
C([N:8]1[CH2:13][CH2:12][C:11]([N:15]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[N:17]([CH3:24])[C:16]2=[O:25])([CH3:14])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH3:24][N:17]1[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N:15]([C:11]2([CH3:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:16]1=[O:25]

참가 물질

4

반응물 1

HCID 866864931-(1-Benzyl-4-methyl-piperidin-4-yl)-3-methyl-1,3-dihydro-benzoimidazol-2-one

생성물 1

HCID 866864941-Methyl-3-(4-methyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one수율 89.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

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온도
50 °C

실험 절차

2.5 g palladium charcoal was added to 4.6 g 1-(1-benzyl-4-methyl-piperidin-4-yl)-3-methyl-1,3-dihydro-benzoimidazol-2-one in 100 mL methanol. The reaction was stirred 3 h at 50° C. and 30 bar under hydrogen. The reaction was filtered and evaporated to yields 3 g of the desired product. (M+H)+: 246

후처리

  1. filtrationThe reaction was filtered
  2. customevaporated

출처 및 근거

ORD 기록
ord-8d97c3252be34a15b6e3a0406495b7a0
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642774B2

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