1,4-Dioxane hydrochloride → 4-[5-(Propan-2-YL)-1,3,4-oxadiazol-2-YL]piperidine

HRID 239130노트

반응식

HRID 239130 반응식
Cl.O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([C:21]2[O:22][C:23]([CH:26]([CH3:28])[CH3:27])=[N:24][N:25]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>O1CCOCC1>[CH:26]([C:23]1[O:22][C:21]([CH:18]2[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]2)=[N:25][N:24]=1)([CH3:28])[CH3:27]

참가 물질

4

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 706506414-(5-Isopropyl-(1,3,4) oxadiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 283449374-[5-(Propan-2-YL)-1,3,4-oxadiazol-2-YL]piperidine수율 116.3%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

100 mL saturated dioxane-HCl was added to 16 g 4-(5-isopropyl-(1,3,4) oxadiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester in 100 mL dioxane at 0° C. The mixture was stirred at RT for 2 h. The precipitate was filtered and washed with ethyl acetate to give 12.3 g of the desired product.

후처리

  1. filtrationThe precipitate was filtered
  2. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-524541ca03804ae0a0e9d4bdc4e86ce6
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642774B2

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